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Exparel and Education to Avoid Opioids After Carpal Tunnel Release

April 5, 2019


This trial aims to use the long acting local anesthetic Exparel and opioid education to avoid any postoperative opioid use following carpal tunnel surgery. This “Exparel” group will be compared with a “Standard” group that receives non-liposomal bupivacaine, opioid education, and opioids.


Study Information

This an interventional, randomized, single blind (care provider) trial with the primary purpose of supportive care with an estimated 64 participants. It includes 2 arms: an active comparator arm for the control group, consisting of bupivacaine and opioids, and an experimental arm for the experimental group that consists of Exparel and no opioids.


Inclusion Criteria

  • Ages 18 and older
  • Have carpal tunnel syndrome diagnosed either by physical exam or EMG


Exclusion Criteria

  • Individuals with an allergy to bupivacaine, Percocet, or acetaminophen
  • Have used pre-operative opioids in the last six months
  • Taking tricyclic antidepressants (interaction with bupivacaine), or
  • Vulnerable to populations (prisoners or pregnant women)



This trial will take place at the Orthopedic Associates of Southwest Ohio in Dayton, Ohio. Contact Laura Peterson via phone at 937-439-6483 or via email at if you have any questions or concerns.



This study is sponsored by the Orthopedic Associates of Southwest Ohio and the American Society for Surgery of the Hand, with Ronald Buczek, DO as the Principal Investigator.

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