There are some ways a person can alleviate the pain of CTS before bed. Consider buying a wrist brace to prevent any unnecessary wrist movements during sleep. Additionally, avoid sleeping on your side as your wrist is more compressed in this position. Finally, try to support your arms when you sleep by propping a pillow under them. This will help alleviate the pressure on them. If you need to address the pain in the middle of the night, use an ice pack on your wrist for 10-15 minutes.